Skovronska A. Clinical and pathogenetic substantiation of early diagnostic methods for hypoxic-ischemic nervous system injuries in newborns

The thesis is devoted to the study of peculiarities of central nervous system hypoxic-ischemic injury clinical course in newborn infants, specifically to the possibilities of improvement its early diagnostics using neurofunctional investigation methods and defining the organism’s energy status. The diagnosis-significant features of the central nervous system hypoxic-ischemic injury in newborns according to the level of severity have been determined for the first time: constriction of the anterior cerebral and basilar arteries at mild and moderately severe injury and dilation of the mentioned vessels in severe cases; diminished electroencephalogram amplitude and reactivity, onset of generalized epileptiform activity, delay of impulse conduction into cortex projection during the registration of evoked visual potentials, and in the area of medial geniculate bodies during the registration of auditory evoked potentials. Activity of intracellular enzymes in newborns depending on the level of severity of central nervous system hypoxic-ischemic injury has been estimated for the first time. The intracellular enzymes’ deficiency has been found in the form of decreasing of mitochondrial enzymes’ activity (succinate dehydrogenase, lactic dehydrogenase), which correlated with severity of the injury. The expediency of succinic acid medications administration in complex treatment of newborns with central nervous system hypoxic-ischemic injury has been proved. Efficiency of preparations of “Glutargin” and “Fitosed” is nosotropic grounded, developed and well-proven for the correction of disorders of the microcirculation, psychological status and prooxide-antioxidation balance in children suffering from Chronic Gastroduodenitis.