Borodach V. Pathophysiological peculiarities of pneumonia course against adrenal myocardial injury and disorders correction

The thesis is dedicated to study of peculiarities of disorders of functional condition of prooxidant and antioxidant systems in lungs, myocardium and phagocytic activity of leucocytes in peripheral blood at experimental pneumonia against adrenal myocardial injury before and after use of corvitin. Еxcessive accumulation of lipid peroxidation products during the all periods of development of adrenal myocardiopathy (1st, 7th and 14th day) was shown and compensatory increase of activity of antioxidant protection ferments in myocardium and in lungs only on the 1st day of experiment with their successive gradual decrease on the 7th and particularly on the 14th day and increase of phagocytic activity of leucocytes in peripheral blood; on condition of combined influence of inflammatory process in lungs substantial deepening of these processes can be observed. Corrective effect of corvitin on abnormal indices of pro- and antioxidant systems and phagocytic activity of leucocytes in pneumonia that developed against adrenal myocardial injury was proven.