Romanova O. Clinico-pathogenetic substantiation of differentiated treatment of genital candidiasis in women of reproductive age.

The work is devoted to an important topic of modern gynecology improve the treatment of acute and chronic vulvovaginal candidiasis in women of reproductive age by studying the clinical and microbiological and immunological changes, enhancements complex diagnostic procedures, as well as by developing and implementing a pathogenetically based treatment on the basis of verification of Candida fungi in different biotopes organism and the properties of local immunity. In a study of women with genital vulvovaginal candidiasis, the dependence of the species composition of fungi of the genus Candida, which contaminate the genital tract, the form of the disease. In the chronic form of vulvovaginal candidiasis in the spectrum of pathogens Candida fungi growing proportion of Candida non albicans. Analysis of the results revealed a conjugate lesion of genital tract and intestinal Candida species in 24.0% of women with acute and 34.0% of women with chronic vulvovaginal candidiasis. The developed complex of therapy based on the account the sensitivity of Candida fungi to antimycotics, has high efficiency, contributes to clinical cure in 96.0% of women, elimination of fungi in 96.0% of surveyed with acute candidiasis and 92.0% of patients with chronic candidiasis and the use of interferon inductors leads to normalization of the local immunological protection. The application of this regimen is clinically important because it leads to the development of an adequate immune response to pathogens, by restoring the fungicidal properties of cervical mucus.