Skotnikova L. Changes of oxidative processes in pathogenesis of systemic disorders caused by surgical trauma under different suture material implantation

The investigation object: the role of surgical suture material (SSM) in systemic oxidative processes disturbances in rats’ organism under surgical trauma. The investigation goal: determining the role of surgical suture material (SSM) in systemic oxidative processes disturbances in rats’ organism under surgical trauma and chronic emotional stress, and substantiating their correction with surgical threads modified with physiologically active substances (mexidol, L-arginine). Methods of research: experimental, biochemical, cytochemical, morphological. The inclusion of physiologically active substances in the implanted surgical threads produces a marked effect on systemic changes of free radical processes in the organism, decreases the products of microsomal and mitochondrial superoxide (mexidol within the catgut), mitochondrial (L-arginine within the catgut), microsomal (triclosan within vicryl plus) electron transport chains in liver cells, and leukocytic NADPH-oxidase in the blood (L-arginine, triclosan) in the early postoperative period. Mexidol and L-arginine availability within the implanted catgut, and triclosan within vicryl plus limit connective tissue disorganization within the gastric mucosa. The degree of implementation: patent, practical innovation.