Kovaleva I. Influence of experimental portal hypertension on development of gastroenterocolonopathy

The investigation object: white rats. The investigation goal: studying of morphofunctional peculiarities of development of gastroenterocolonopathy in experimental portal hypertension. Methods of research: experimental modelling od portal hypertension, detection of portal vein pressure, ultrasound dopplerometry, laser doppler flowmetry, histologic studying of liver, stomach, small and large intestine, statistic methods. Theoretical and practical value of the obtained results. Method of modelling of chronic diffuse liver disease and portal hypertension on base of chronic chloroform intoxication in rats is modified. Method of detection of microcirculation in skin, liver, stomach, small and large intestine with the help of laser doppler flowmetry of rats is modified. Method of food test and detection of functional liver reserve by ultrasound dopplerometry is elaborated. Method of detection of indexes of central hemodynamics in animals is proposed. Scientific novelty of the obtained results: The experimental research directed onto studying of role of portal hypertension in development of gastroenterocolonopathy on base of chronic chloroform intoxication is finished. It was established that the development of chronic diffuse liver disease and portal hypertension is a cause of inflammatory, atrophic and destructive changes in mucosa of stomach, intestine and colon. Severe changes of submucosal veins and atrophy of mucose above them might be cause of acute nonvaricose bleeding. The relation between disturbances of portal hemodynamics and changes of microcirculation in the wall of stomach, intestine and liver surface was showed. Changes of microcirculation in skin of experimental animals for certain affected their changes in the liver and in the wall of digestive tract. The central hemodynamics of animals and their reaction on food test in experimental portal hypertension was studied by Doppler ultrasound. The degree of implementation: Results of research are inculcated in studying process and scientific work in Chairs of pathological physiology of high education institutes of Ukraine.