Soltyk S. Peculiarities of phospholipid composition of the hepatocyte membranes, processes of lipid peroxidation and antioxidant system in toxic hepatitis and their correction

The thesis deals the study of the main pathophysiological mechanisms of development of toxic fluconazolum-induced hepatitis and acute hepatitis B (AHB). The experimental studies were made on male rats. They were intraperitoneally injected by 0,2 % solution of fluconazolum in dose 3 mg/kg during 5 days, which led to acute toxic hepatitis. It was found out that such model of hepatitis, judging by its biochemical and morphological changes, resembles the dysfunctions, which are observed in case of viral hepatitis. It is shown that in acute toxic hepatits and AHB the residual quantity of free radical oxidation products exerts a toxic influence on the phospholipid composition of the membranes and functional ability of not only hepatocytes but also erythrocytes. At the same time there is a disbalance of synthesis and degradation of the phospholipid pool resulting in substantial morphofunctional changes in these cells. Hepatoprotector glutarginum was administered to correct the established disturbances. The application of the drug contributed to normalization of the lipid peroxidation products concentration accompanied by positive antioxidant effect and restoration of the content of separate fractions of phospholipids.