Zead H. Pharmacognostic studies of Chamerion angustifolium (a willow-herb )

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0412U003382

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

11-05-2012

Specialized Academic Board

Д 35.600.02

Danylo Halytsky Lviv National Medical University

Essay

Phytochemical studying of leaves was carried out during flowering stage, buds and flowers of Chamerion angustifolium with research of different groups of biologically active substances for creation of medicines on their basis. In individual condition 20 substances were isolated from Сhamerion angustifolium raw materials: 2 derivatives of benzoic acid; 4 derivatives of cinnamic acid; 1 catechin; 1 anthocyanin; 7 flavonoides; 2 triterpenoids; 1 steroid; 2 chlorophylls. Quantitative studying of the polysaccharides maintenance, the sums of oxidized polyphenols, derivatives of cinnamic acid, flavonoides, ascorbic acid, 15 macro - microelements, 17 amino acids, 4 unsaponifiable and 62 volatile substances was carried out. Lipophilic fractions from different part of Сhamerion angustifolium were received. Their qualitative structure and quantitative analysis showed the presence of 10 fatty acids, chlorophylls and carotenoids. It was established the technological parameters and a choice of extractant and its ratio, temperature and term of extraction for flowers of Сhamerion angustifolium. It was studied sharp toxicity and reparative action of a water extract from flower Сhamerion angustifolium. The parameters of standardization for flowers of Сhamerion angustifolium were defined and was developed the project of the Method of quality control "Flowers of Сhamerion angustifolium" on their basis.

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