Dzhan T. Pharmacognostic characteristic of quince Cydonia oblonga Miller and Japanese quince Chaenomeles speciosa (Sweet.) Nak. and development of substances based on them

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0412U003408

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

20-04-2012

Specialized Academic Board

Д 26.613.04

Essay

First conducted a systematic pharmacognostic study of fruits, seeds, leaves and flowers of 2 sorts of quince and 5 sorts of Japanese quince included in the State Register of sorts of Ukraine. In the studied feedstocks established presence and quantify the content of carbohydrates, amino acids, fatty acids, aliphatic and hydroxycinnamic acids, procyanidins, tannins, flavonoids, saponins, chlorophylls, carotenoids, macro- and microelements, in leaves of Japanese quince, flowers of Japanese quince and quince - for the first time. From leaves of Japanese quince in individual state obtained 26 compounds: 5 organic acids, 9 hydroxycinnamic acids, 6 flavonoids, 2 triterpenoids, 2 sterols and 2 chlorophyll. All substances marked the first time. For the first time determined the composition of lipophilic extracts of Japanese quince fruits, in which identified 17 substances of different classes. Total amount of BAS identified in quince and Japanese quince is 83 compounds: 9 hydroxycinnamic acids, 6 flavonoids, 17 amino acids, 13 fatty acids, 2 esters of fatty acids, 8 aliphatic acids, 4 triterpenoids, 2 steroids, 2 chlorophylls, 7 hydrocarbons, 1 aromatic compounds - naphthalene derivatives, 1 phenolic compounds, 5 heterocyclic compounds - derivatives of oxyran and chroman, 6 monosaccharides; herewith 67 substances in leaves of Japanese quince, flowers of Japanese quince and quince are identified for the first time. For the first time in quince and Japanese quince identified lectins and their contents determined by the hemagglutination reaction. BAS accumulation in leaves of quince, leaves and fruits of Japanese quince is conducted and optimal time of harvesting is determined. Dry extracts from leaves of quince and Japanese quince are obtained, for them acute toxicity, anti-inflammatory, analgesic and hepatoprotective effects are defined. Dry extracts of Japanese quince fruits with certain stimulatory effects on hematopoiesis are obtained. Developed projects "Leaves of quince," "Leaves of Japanese quince ", "Dry extract of quince leaves," "Dry extract of Japanese quince leaf", "Fruits of Japanese quince", "Dry extract of Japanese quince fruit."

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