Object of study: peculiarities of pinoxaden, picoxystrobin, trinexapac-ethyl behavior in environment during its application in cereal crops chemical protection systems, pecticides influence on test animals’ and workers’ health. Purpose: toxicological and hygienic assessment and substantiation of hygienic standards and regulations for pinoxaden, picoxystrobin, trinexapac-ethyl safe application in high technologies for cereal spiked crops protection with the view of workers’ and population health and environmental protection. Research methods: bibliographical, toxicological analysis, laboratory and full-scale hygienic experiment, organoleptic, sanitary and chemical, sanitary and microbiological, chromatographic, clinical and diagnostic, statistical. Theoretical and practical results: toxicological properties of new pesticides pinoxaden, picoxystrobin, trinexapac-ethyl and preparations on its base (Axial, Acanto Plus, Moddus) were established. For the first time the classes of hazard were determined on the basis of toxicological and hygienic assessment and required magnitudes of threshold and subthreshold doses to calculate their allowable daily intake for human were established; for the first time the studies of pinoxaden, picoxystrobin, trinexapac-ethyl influence on the organoleptic properties of water and the water reservoirs self-purification processes were conducted; for the first time in the soil and climatic conditions of Ukraine patterns of pinoxaden, picoxystrobin, trinexapac-ethyl behavior in agrocoenosis objects during Axial, Acanto Plus, Moddus application were determined with establishment of residues dynamics types and determination of their stability in soil and cereal plants; for the first time the hygienic assessment of working conditions during application of the studied preparations on cereals by rod processing was given with setting the potential risk of a.i. adverse effects on the workers’ organism at the complex intake by the respiratory tract and skin and it was determined that the potential risk is less than 1 and is acceptable; for the first time the optimal conditions of picoxystrobin samples extraction from air, water, soil, green mass of plants and grain of cereals, extracts cleaning, chromatographic separation, detection and quantitative determination by methods of gas-liquid (GLS) and thin-layer (TLC) chromatography were determined. The practical significance of the results is scientific substantiation of: pinoxaden, picoxystrobin, trinexapac-ethyl ADI values for a human; pinoxaden, picoxystrobin, trinexapac-ethyl TSELs in working zone air and in the atmospheric air; pinoxaden, picoxystrobin, trinexapac-ethyl MACs in the water reservoirs; MRLs of the studied substances in cereal grain; pinoxaden, picoxystrobin, trinexapac-ethyl TACs in soil; hygienic regulations (waiting periods to harvest, re-entry periods) for Axial, Acanto Plus, Moddus application. Scope (area) of use: in the institutions of the sanitary-epidemiological service and environment protection institutions
