Pionova O. Postprandial glycemia, lipemia, and apolipoproteinemia in patients with arterial hypertension with obesity.

Dissertation is devoted to optimization of cardiovascular risk diagnostics, metabolic abnormalities prognosis in hypertensive patients with obesity on the base of postprandial glycemia, lipemia and apoproteinemia parameters, insulin resistance presence investigation, and determination of these factors role in formation of vascular remodeling. It was detected that abdominal obesity promote carbohydrates metabolism disorders development and progression in arterial hypertension, that characterized by carbohydrates intolerance, basal and postprandial hyperglycemia, hyperinsulinemia, and insulin resistance. Abdominal obesity role in formation of atherogenic dyslipidemia, postprandial lipemia, proatherogenic and antiatherogenic apoproteins dysbalance and carotid arteries structure-functional parameters changes was found in patients with arterial hypertension. The most informative criteria that characterized proatherogenity of lipid metabolism changes in the patients with arterial hypertension with concomitant obesity was increased apoprotein B levels, reduced apoprotein A-I content and elevation of integral parameter - apoprotein B/apoprotein A-I ratio (Avogaro index). It has been evaluated that postprandial insulinemia promotes vascular remodeling development, and intima-media complex sickness represent surrogate marker of this process.