Sadovoy V. Structural and functional characteristics of the heart and levels of cardiotropic growth factors in early postinfarction period

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0412U003857

Thesis Registration Form

0412U003857.pdf

Applicant for

Specialization

  • 14.01.11 - Кардіологія

22-06-2012

Specialized Academic Board

Д 52.600.01

Essay

The total of 117 patients with coronary artery disease have bee enrolled: 75 patients with 1 month old myocardial infarction (MI), 42 patients with stable angina pectoris of II-IV functional class without history of MI. Control group included 20 persons without cardio-vascular pathology. It has been shown that serum levels of transforming growth factor ? (TGF-?) and hepatocyte growth factor (HGF) are associated with size and systolic function of left ventricle in 1 and 6 months after MI. Positive correlation of TGF-? level and negative correlation of HGF concentration with severity of coronary atherosclerosis have been revealed as well. Analysis of the associations of TGF-? and HGF serum levels with severity of cardiac remodeling, clinical course and outcomes in the period up to 12 months after MI has shown that low levels of TGF-? and HGF in 1 month after MI are of a predictive value for progression of chronic heart failure within 12 month period.

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Files

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Dis.doc

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