Farat O. Reactions of substituted 2-spiro-4-oxo-pyrimidines

By the reaction of 5',6',7',8'-tetrahydro-1'H-spiro[cyclohexane-1,2'-quinazolin]-4'(3'H)-one with Mannich’s reagent with different amines a number of polycycles derivatives of 3-azabicyclo[3.3.1]nonane is got at the hydrolysis of which the analogues of natural alkaloids appear. It is set that reaction of Mannich 5',6',7',8'-tetrahydro-1'H-spiro[cyclohexane-1,2'-quinazolin]-4'(3'H)-one flows on the atom of Carbon, but not Nitrogen as became firmly established before. Treatment of 5',6',7',8'-tetrahydro-1'H-spiro(cyclohexane-1,2'-quinazolin)-4' (3'H)-one with POCl3 and DMF gives a mixture of 1,2,3,4,5,6,7,8-octahydroacridine-4-carbonitrile and 4,5-diformyl-2,3,6,7,8,10-hexahydroacridine-8a(1H)-carbonitrile, both products resulting from cascade transformations of the primary Vilsmeier intermediates.