The investigation object: pathogenesis psoryaza. The investigation goal: To clarify the regularities of changes of different types of metabolism and the functioning of a number of humoral regulatory systems and identify the most important pathogenetic humoral mechanisms of metabolic disorders in psoriasis. Methods of research: biochemical, chromatographic, enzyme immunoassay, immunofluorescence, statistics. Theoretical and practical value of the obtained results. The thesis is fundamental. The results extend and deepen the current understanding of the pathogenesis of psoriasis and, therefore, relevant to the pathophysiology and, as a theoretical foundation for the clinic. Also found that the most informative and dynamic under the influence of conventional treatments for psoriasis are indicators of content in serum creatinine, urea, ALT activity, AST, CPK – MB levels of prolactin and somatotropin, that allows to recommend their use as monitoring prognostically significant criteria in assessing the severity of psoriasis and the effectiveness of therapy. The results can be used in further R & D and teaching in pathophysiology, endocrinology and other medical sciences, and to further develop and improve methods of pathogenetic treatment of psoriasis. Scientific novelty of the obtained results: First it is shown that in psoriasis there are profound changes in the metabolism of tryptophan, which shows a significant increase in serotonin way exchange, increase the quantity of melatonin. At the same time greatly increases the level yndykanu in the blood that may indicate a strengthening of the processes of putrefaction of proteins in the intestine. Changes in metabolism of tryptophan in the background dyzbiozu in the digestive tract may be an important link in the pathogenesis of psoriasis. A common psoriasis exacerbation characterized by disturbance processes transamination and deamination of amino acids, ammonia neutralization mechanisms, as evidenced dyzbalansom contents dicarboxylic amino acids and their amide, reduction of serum arginine, ornithine and urea and ammonia accumulation. In psoriasis there is increased production of hormones that enhance the proliferative properties of keratinocytes (prolactin, somatotropin, iodine thyroid hormones). There is a violation homeostatic regulation of the immune system, as evidenced by changes in correlations between components of the cytokine profile and seen as hyperactivation of cellular and humoral immunity. The degree of implementation: The results are implemented at the Department of Pathologic Physiology of Kharkiv National Medical University Crimea State Medical University. Georgievsky (Simferopol), Ternopil State Medical Academy. I. Kovalchuk, Sumy State University.
