Bocharova V. Early diagnostic of exacerbation and complex immunomodulation therapy of atopic dermatitis

Object of research - atopic dermatitis. Research objective - increase of treatment efficiency of atopic dermatitis by development of complex immunomodulatory therapy methods on the ground of establishment of the role of neopterin and cytokine as early diagnostic criteria of phlogistic and reparative process and pathogenetic factors of disease. Research methods: clinical, common laboratory, immunological, statistiacal. The dissertation is devoted to scientific problem solution of improvement of diagnosis methods of inflammatory-reparative processes in the skin, as well as increasing the efficiency of therapy of atopic dermatitis by developing a comprehensive method of treatment including immune disorders by use of immunomodulators and means to strengthen the immune defense. It was determined that patients with atopic dermatitis with IgE-dependent type have more distinct change from the "early" inflammatory markers neopterin and cytokines of different functions and origins, and the existence of correlations between laboratory performance bonds and clinical data confirms the indication of neopterin as "early" diagnostic marker of inflammatory reactions in atopic dermatitis. Results have been implemented in the practice of Zaporizhzhya, Poltava Regional and the Donetsk city of clinical dermatovenerological dispanseries, Dnipropetrovsk city clinical hospital №17, dermatovenereological department of Romny central regional hospital of Sumy region, and also in the pedagogical process of department skin and venereal diseases of Dnipropetrovsk State Medical Academy and department professional diseases and radiation medicine of Donetsk National Medical University named after M. Gorky. Use area - dermatovenerology.