Shlimkevych I. Structurally are functional mechanisms of adaptation for children with the different variants of hyperpiesis

The thesis is devoted to one of the important tasks of Pediatrics - improving diagnosis and treatment of hypertension of children and adolescents. The paper applied an integrated approach to the assessment of clinical and functional and structural and morphological changes which are characteristic of different variations of arterial hypertension of children. Biological and social risk of development of different variants of hyperpiesis factors are defined, that will allow prophylaxis development of hypertension in high-risk groups. The features of vegetative changes, phsycloemotional status and cognitive sphere are studied they are depended on the variant of hypertension and it is set that for patients with the hypothalamic syndrome of пубертатного period emotionally-affected violations prevail at in relatively to moderate vegetative changes, for patients with neurocirculatory dystonia the symptoms of vegetative prevail, and examined patients with a primary hypertension the expressed changes in both spheres. The paper identified early structural-functional mechanisms of adaptation in children depending on the version of hypertension-based indicators of central, peripheral and cerebral hemodynamics in statics and under stress loading. It is shown that the pathogenic mechanisms in the development of hypertension in children is endothelial dysfunction, hipersympatykotoniya, imbalance in the system of peroxidation, dyselektrolitemiya proaterohenna and dyslipidemia. In the study, pathogenetically substantiated, developed and implemented an improved scheme of treatment of childhood with variations of hypertension with the inclusion of complex drug therapy drug metabolic actions hlitsysed and vazotropnoho drug vinpocetine.