Chernyashova V. Pathogenetic substantiation of L-arginine-L-glutamate and superoxide dismutase usage for the liver and kidney damage correction in experimental peritonitis.

Dissertation is dedicated to the studying of peculiarities of the pathogenesis of liver and kidney damage in acute peritonitis and establish the impact of synthesis of nitric oxide precursor – L-arginine-L-glutamate and superoxide dismutase on the experimental pathology. Found that experimental acute peritonitis accompanied by activation of lipid peroxidation, decreased activity and content components of the antioxidant system and inhibition of utility processes of mitochondria in the liver and kidneys, amid growth in serum indices content of endogenous intoxication and proinflammatory cytokines (TNF-?, IL- 1?, IL-6), reduction of anti-inflammatory interleukin (IL-10) and inhibition of nitric oxide synthesis. L-arginine-L-glutamate (LALG) helps to restore the original ratio of the components of pro-oxidant-antioxidant, activity of mitochondrial enzymes in the liver and kidneys, which comes amid growing content of NO2-, IL-10 and reduced levels of endogenous indicators of intoxication. Aminoguanidyn (AG) causes further progression of liver and kidneys. SODrec drug reduces the degree of destruction of the internal organs of animals. In combined use LALG SODrec and their positive effects on the liver and kidneys of the animals increases, which is due to exogenous supply of the active form of SOD and decrease superoxide anion radical (О2–) and restoration of synthesis NO. In contrast, the positive impact on the state LALG liver and kidneys when used in combination with AG reduced, which may be due to blockade of endogenous NO formation process and the latest evidence of the importance of this process in the implementation of protective actions LALG acute peritonitis.