Barsukov A. Histo- and organogenesis of human maxillo-facial apparatus during early period of prenatal development.

The dissertation deals with a complex study of the thesis is dedicated to complex research of characteristics of morphological reconstructions in human maxillofacial apparatus during the first trimester of prenatal development starting from isolation of its embryonic anlages with 21-days embryos, when bilaterally located anlages of the first branchial arch and brow tine, which limit stomodaeum, are being well determined. During 5th week distal ends of mandibular appendages approach each other maximally and on the 6th week they merge by the midline. As a result mandibular is being formed, in proximal divisions of which formation of Meckel's cartilage is being defined. At the end of 7th week convergence of maxillar appendages with lateral and medial nasal processes and brow tine is going on, in consequence of which maxilla and labrum are being formed. During the same period mimic and masticatory muscles manifest itself. Osseous basis of maxilla and mandibula starts to enisle on 6th week and at the end of the first trimester becomes fully formed already. At the 10th week of human fetal development mandibular branches develop, formed of hyaline cartilage, which starts to be replaced by osseous tissue on the 12th week. Morphogenetic transformations in structural components of human maxillo-facial apparatus are being accompanied by regular phased complication of synthesis of energy and plastic biopolymers and change of caryometric measurements, which totally mirrors their qualitative and quantitative reconstructions.Obtained information let us to establish critical periods of development of structural components of maxillo-facial apparatus and heterochrony of their morphological transformations in maxilla and mandibula.