Antonyuk M. Clinical, Diagnostic and Treatment Features of Cervical Intraepithelial Cervix Uteri Neoplasias, complicated by cervicitis

Dissertation thesis is dedicated to the problem of present gynecology - diagnostics and treatment in CIN with cervicitis at the background. Clinical and diagnostic features of patients with CIN complicated by cervicitis were established. When inflammatory processes of cervix uteri accompanied by dysplastic changes are having place cases of HPV diagnosing are the most commonly combined with mycoplasmic infection and primarily Ureaplasma urealyticum (39,9 %). While the diagnostic intensities of mycoplasma, gardnerela and fungi species Саndida albicans were approximately the same, the frequency of herpes virus (HVI + CMV) detection in Cervicit + CIN group was up to twice as much as in CIN group, respectively 9,8 % and 4,6 %. Citomorphological analysis of results received from examined patients showed that index of concomitant reparative atypical cells vary from 13 to 26 % in mild inflammation and from 92 to 100 % in severe inflammation. Index of positive reaction to causative agent relatively to inflammation stage grows proportionally to severety stage of CIN in CU. Characteristics of immune system functioning, immunocompetent cells condition, their ability to produce different mediators have been established. There were also established: peripheral blood neutrophilic dysfunction, immunoregulative index СD4+/СD8+ decrease, changes in humoral immunity parameters and oppression in endogenous alfa- and gama-interferon production with the growth of TNF- output. It has been proposed the new mode of CIN of CU with cervicitis at the background treatment, that supposes etiotropic treatment, electrosurgical excision procedure and antiviral plus immunomodulating therapy, that resulted in 93,5 % recovery in parients treated.