Svergun N. Immunological and molecular-genetic factors of Hodgkin’s lymphoma prognosis

The thesis is dedicated to the identification of new additional prognostic factors of Hodgkin’s lymphoma. Immunological criteria for the prognosis of Hodgkin’s lymphoma were first determined, which include the definition of patient’s factors before the treatment that characterize the status of native and specific types of immune system. It was ascertained that the critical decrease of B-cells in the peripheral blood of patients to less than 0,042*10-9/l and the decrease of the ratio (CD56+CD16+CD3+ + CD56+CD16+CD3+) / CD25+CD4+Foxp3+ to less than 9 are associated with the risk of disease relapse for the Hodgkin’s lymphoma patients independently from the stage of the disease. The distribution of GSTP1 polymorphic variants for Hodgkin’s lymphoma patients in Ukraine was first investigated. It was first ascertained that homozygous wild genotype of GSTP1 gene (A/A) is associated with a poor response to the therapy and a risk of the relapse. Defined in this thesis markers that characterize the status of patient’s immune and detoxication systems could be included in Hodgkin’s lymphoma prognostic models that will provide early and precise patient’s stratification into risk group for therapy intensification in patients with poor prognosis and the possibility of significant decrease of treatment amount in patients with good prognosis. Key words: Hodgkin’s lymphoma, prognosis, immune system, genetic polymorphism, GSTP1 gene.