Kutovyi V. Circulating antibodies and markers of inflammation in chronic heart failure: clinical significance and changes in the background of pharmacotherapy

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0412U006381

Thesis Registration Form

0412U006381.pdf

Applicant for

Specialization

  • 14.01.11 - Кардіологія

20-11-2012

Specialized Academic Board

Д 26.616.01

State Institution National Scientific Center "The M.D. Strazhesko Institute of Cardiology National Academy of Medical Sciences of Ukraine"

Essay

The work is devoted to the improvement of practical recommendations for the treatment of CHF due to AH and IHD based on assessment of the impact of various options of pharmacotherapy on the severity of myocardial damage, inflammation reaction and anemic syndrome by determining blood concentration of circulating antibodies to cardiac myosin, Hsp60, Hsp90, protein hBD-2, inflammation markers and anemia. An examination of 101 patients with CHF found that antibodies concentration depends on the patients' gender and age, the severity level of CHF, the heart rhythm nature, pharmacotherapy. The greatest reduction of the investigated antibodies, inflammation markers were observed in applying of the combination (ACEI, BAB, BRAII, D). The use of MRA in the combination (ACEI, BAB, D) contributed to more significant reduction of the antibodies concentration, inflammation markers.

Read more

Files

Автореферат_Кутовой ВВ.doc

Диссертация В.В. Кутовой.doc

Similar theses

0524U000129

Oksana L. Rekovets

Сlinical and pathogenetic justification of individual diagnostic approaches and treatment programs in resistant arterial hypertension

0523U100016

Maslovskyi Valentyn Iuriyovych

Prognostic value of various clinical and instrumental markers and options for basic therapy to assess the quality of life and the nature of the course of myocardial infarction without elevation of the ST segment

0421U103208

Kovbasniuk Yuriy Vasylovych

Structure and functional myocardial changes and features of plasma hemostasis by patient with atrial fibrillation and different body mass index

0821U101742

Tanska Olha Oleksandrivna

Criteria for Patients to be Put on the Waiting List for Heart Transplantation

0821U101115

Kutia Inna Mykolaivna

Pathogenetic and prognostic value of vascular endothelial growth factor-A in acute myocardial infarction with the ST segment elevation