Miakota N. Gestation course and characteristics of hemostasis system in women with fetuses irradiated in utero.

Dissertation is devoted to the study of a problem being among the most actual ones in gynecology and concerning the frequency decrease of obstetric, thrombohemorrhagic, and perinatal complications in pregnant women with fetuses irradiated in utero because of situations due to the Chernobyl catastrophe. The dissertation deals with studies of hemostasis system, immunocytokines, fetoplacental system functions, and thyroid gland, their associations with radiation load and gestation period when future mothers have been evacuated from the radiation accident zone. It is proved the pregnant women with fetuses irradiated in utero demonstrate the decrease of platelet quantities, increase of their adhesive and aggregative activity, appearance of fibrinogen degradation products their blood as well as of soluble fibrin-monomer complexes, decrease of anti-thrombin III activity, and elongation of activated partial thromboplastin time. The author has discussed several criteria for early diagnostics of pathological hemorheology changes. Some essential disturbances of fetoplacental complex (decrease of estrogenic saturation, drop of indices concerning fetus biophysical profile, changes for the worse in circulation between uterus, placenta, and fetus). Several criteria of early determining of fetus state impairs have been proposed.The author has elaborated a complex of treatment and prophylactic measures aiming to correct hemorheological changes as well as impairs of thyroid gland and fetoplacental complex detected in pregnant women in order to decrease the complication frequency for fetuses and women with in utero-irradiated fetuses, the complex use having been demonstrated to be effective.