Lytvynets O. The Secondary mitochondrial dysfunction in children with chronic incorporation of radioactive cesium 137

It was founded that high level of cesium in the body lead to inhibition of energy production with aerobic process, compensatory activation of the glycolytic, more active involvement in the process of energy production of lipids and amino acids. It is shown when the content of 137Cs in the body from 1000 to 3000 Bq compensatory mechanisms are sufficient to provide the cell's energy needing of biosynthetic process. For all that, cellular energy status is compensated. Biosynthetic processes don't increase when the concentration of 137Cs is within the limit 7000 Bq and it is depressed when the level of 137Cs is above 7000 Bq. The dehydrogenase activity depends from the incorporated 137Cs level. It was noted, chronic 137Cs incorporation leads to cell membranes destabilization and lymphocytes organelles ultrastructure disruption, which leads to energy production of inhibition as a result of mitochondrial dysfunction developing. This process was accompanied with increase levels of lactate and pyruvate in conditions with high physical activity. The levels of initiated chemiluminescence of blood serum and erythrocytes elevated also. The secondary mitochondrial dysfunction correction was proposed and their efficiency was demonstrated.