Sosnytska T. Magnetocardiographic indices of evaluation of disturbances of electro-physiological myocardium properties in different clinical forms of ischemic heart disease

In this dissertation solution of such an up-to-date scientific task in cardiology as improving diagnostic efficiency of IHD based on relationship between electrical hyperheterogeneity of myocardium and space-temporal organization disorders of ventricular excitation in different clinical forms of IHD, using the new methodological approach - analysis of dynamic of changes of global and maximal current density according to MCG data, is presented. Based on the new methodological approach during the studies the most informative MCG-criteria of space-temporal organization of myocardium excitation in patients with IHD have been proposed. The complex MCG-index (CI) with the diagnostic value of 85% (PPV) and 93% (NPV) of prognosis of hemodynamically significant stenosis according to coronary angiography data in patients presenting mediate pretest probability of IHD has been developed. The usage of the new MCG-criterion allowed making prognosis of results of stress-testes (tredmil-test, Stress-Echo) in patients with different clinical forms of IHD.In the dissertation the usage of the new MCG-markers of local excitation disturbances and transmural hyperheterogeneity of repolarisation in predicting ventricular arrhythmias maintenance and further IHD state was showed.