Ben A. Experimental and clinical substantiation of a new prophylactic method for diabetic cataract progression

Object: age-related cataract, diabetes. Purpose: to prove the amino acid glycine feasibility in the system of diabetic cataract medicamentous prophylaxis based on exploring a possible stabilizing protective effect of given amino acid on the lens, antioxidant enzymes in cataractogenesis. Methods: ophthalmologic, biochemical methods, clinical, statistical. It was shown that the effects of light energy causes a significant impairment of the state of the lens's enzymatic antioxidant system in animals with experimental diabetes compared with non-diabetic animals. Found that glycine in the experiment has a significant protective effect on the lens components, resulting in a decrease in inactivation degree of the antioxidant system in the lens at diabetic cataract modeling. Decrease the level of glycine was revealed on 31,2 % in the cataract lens of diabetic patients. The relatively lower level of activity of antioxidant enzymes in the lens of the patients was 25.6% for superoxide dismutase, catalase - 17.0%, glutathione peroxidase - 32.1%. Direct correlation between the level of glycine and indices of antioxidant enzyme activity was found in the lens of diabetic cataract. The results of experimental, clinical and biochemical studies substantiate the feasibility of glycine application in treatment of diabetic patients with initial forms of cataract. Results of the work were implemented at the SI "The Filatov Institute of Eye Diseases and Tissue Therapy of NAMS of Ukraine." Sphere of application - medicine, ophthalmology.