Trubich N. Pathogenetic features of acute acetaminophen poisoning on the background of prolonged intoxication salts of lead and cadmium and its pharmacological correction.

Object - acute acetaminophen poisoning against prolonged exposure of lead and cadmium salts in subthreshold doses, the goal - to establish pathogenic features of acute experimental poisoning acetaminophen under the previous long-term administration of cadmium chloride and acetate of lead in subthreshold doses; methods - immunoassay, chemistry, mathematics and the results - the first time the peculiarities of metabolic disorders in conditions of acute experimental poisoning acetaminophen on a background of chronic intoxication with salts of lead and cadmium, for the first time found that acute acetaminophen poisoning after administration of cadmium chloride and Lead acetate for 30 days followed by a much more expressive changes in activity processes of energy, greater intensity of lipid peroxidation, depletion of enzyme components and parts nefermentnoyi antioxidant system, the disintegration of cellular and subcellular membranes than the effect of each of these factors, in particular, for the first time demonstrated the effectiveness of correcting violations caused by Thiotriazoline alginate and calcium for the first time shown that the introduction Thiotriazoline positive effect on metabolic parameters in blood and liver of affected animals.