Antonenko A. Hygienic substantiation of safe use regulations of modern herbicides in chemical defense systems of maize

Research object: is patterns of herbicides Stellar, Adengo 465 SC and MaizeTer Power OD, its active ingredients and antidote environmental behavior, toxicity and hazard to workers, human health and environment under their usage for maize protection. Methods: method of model and laboratory hygienic experiments, physicochemical (chromatographic), organoleptic, sanitary-chemical, sanitary-microbiological, physical methods, the method of mathematical modeling and statistical analysis, bibliographic method. Theoretical and practical results: toxicological and hygienic assessment of topramezone, isoxaflutole, thienecarbazon-methyl, foramsulfuron, iodsulfuron-methyl sodium and cyprosulfamide were conducted, based on theoretical information; hygienic classification of the studied compounds and pesticides was made on base of their danger degree; acceptable daily intakes, safe exposure levels in the air of the working area and atmosphere air, the maximum allowable concentrations in corn grains and oil of topramezone, thienecarbazon-methyl and cyprosulfamid were justified; tentatively permissible concentration in soil, the maximum permissible concentration in water of topramezone and thienecarbazon-methyl were also justified; risk of adverse effects of studied pesticides for those who works with Stellar, Adengo 465 SC and MaizeTer Power OD were calculated. The methods of topramezone, thienecarbazon-methyl and cyprosulfamid determination in environmental objects and food products were worked out. Scientific novelty: comparative assessment of toxicity and metabolism of modern herbicides inhibitors of acetolactatsynthetase and 4-hydroxyphenilpiruvatdioxigeneze in the organism of warm-blooded animals and environmental objects were conducted for the first time. It allowed to justify ADI of topramezone, thienecarbazon-methyl and cyprosulfamid for human; peculiarities of behavior of these substances in agrocenosis objects of different soil and climate ones of Ukraine were determined and assessment of their ecotoxicological hazard was conducted; professional risk of studied pesticides for professional communities was. Level of inculcation: results are inculcated in 2 patents on utility model, 12 officially certified methodic recommendations for studying herbicide determination in environmental objects and food products. Sphere of application: hygiene, agriculture and medicine.