Dorofeyev D. Pathophysiological peculiarities current of community-acquired pneumonia at children with acute and chronic stress.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0413U001816

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

14-03-2013

Specialized Academic Board

К 76.600.02

Essay

Object children who during a life were ill a pneumonia and passed treatment in the specialized branch of a hospital; the purpose - to find out pathophysiological features of active inflammatory process, temperature reaction of an organism, infringements of gas structure of blood, osmolar concentration of plasma of blood, electrolits of blood and frequency of occurrence of a syndrome of sharp respiratory insufficiency, toxic, hyperthermal, obstructive, syndromes from children with stress of patients with a pneumonia; methods - clinical, laboratory, tool, bacteriological, methods which allow to reveal sharp and chronic stress; biochemical, mathematical; results - based on the comprehensive survey of 137 children with community-acquired pneumonia was identified in first and was described pathophysiological peculiarities of pneumonia at children with stress; was found that at children with stress in the inflammatory process in the lung was observed pathophysiological features of the temperature response of the organism. In addition, at patients with pneumonia in children with stress was marked by more pronounced changes in the degree of oxygen saturation of hemoglobin in arterial blood, partial pressure of oxygen in arterial blood, partial pressure of carbon dioxide in arterial blood. more pronounced a change of these physiological characteristics was observed in children with pneumonia with chronic stress; the combination of pneumonia with stress was led to a more pronounced change in important indicators of homeostasis, such as: PH-blood, level of buffer systems, electrolytes, blood osmolar concentration of blood plasma; revealed that the pathophysiological features current of pneumonia at children with stress include a more pronounced activity of the inflammatory process in the beginning of the disease at children with acute stress and the longer the activity of inflammation in the lungs at children with pneumonia with acute and chronic stress; revealed that more severe pathophysiological changes at children with pneumonia with stress was led to the fact that these patients significantly more often to have symptoms of life-threatening patient; hyperthermia syndrome at children with pneumonia with acute and chronic stress arose at 3.8 times more often than children with pneumonia with a satisfactory adaptation, syndrome of acute respiratory failure at children with pneumonia with acute stress arose in 2 times more often, at children with pneumonia chronic stress in 2.3 times more often, toxic syndrome at children with pneumonia with acute stress arose in 3.8 times more often, obstructive syndrome at children with pneumonia with chronic stress arose in 2.7 times more often; thus, the pathophysiological features of current community-acquired pneumonia at children with stress reasonable take into consideration in the theoretical description of the disease and in medical practice.

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