Ben S. Etiological diagnosis of vaginal imbalance and forecasting of infectious and perinatal complications in pregnant women with bacterial vaginosis.

The thesis for the first time shows the results of etiologic diagnosis of vaginal imbalance in pregnant women with bacterial vaginosis in real time using a diagnostic test of the "polymerase chain reaction in real time". The following types of vaginal microbs community have been determined: normal - in 34 (32,6 %), moderate vaginal imbalance of anaerobic type - in 24 (23 %), pronounced vaginal imbalance of anaerobic type - in 46 (44,2 %). Leading obligate - anaerobic microorganisms at moderate vaginal imbalance were - Gardnerella vaginalis (lg 7,92 ± 0,16 units / ml), Mobiluncus spp. (Lg7, 53 ± 0,3 units / ml), Lachnobacterium spp (lg 7,31 ± 0,3 units / ml), Eubacterium spp (lg 7,41 ± 0,21 units / ml), Peptostreptococcus spp (lg 6,7 ± 1,3 units / ml). In patients with severe vaginal imbalance leading obligate-anaerobic conditionally pathogenic microbs were Gardnerella vaginalis (lg 7,78 ± 0,29 units / ml), Megasphera spp. (lg 7,23 ± 0,12 units / ml ), Peptostreptococcus spp (lg 6,1 ± 0,22 units / ml). The direct correlation between these types of imbalances with infectious and perinatal complications in pregnant women with bacterial vaginosis has been established: threat of spontaneous abortion and preterm labor - 12 (11.5 %), preterm rupture of amniotic membrane - 18 (17,3 %), subinvolution of puerperal uterus - 8 (7,7 %), decreased Apgar scores - 8 (7,7 %). Expressed vaginal imbalance of anaerobic type was a high risk for complication. Conducted studies have clearly identified the need of etiological treatment of bacterial vaginosis (antianaerobics, probiotics, antiseptic sanitation of the birth canal before delivery.)