Prodan S. Diagnosis and treatment optimization in patients with liver injury (experimental and clinical studies).

Object - traumatic injury of the liver; purpose - to improve the results of surgical treatment of patients with traumatic injuries of the liver by improving the diagnostic-treatment policy and optimal choice of surgical hemostasis; methods - clinical, laboratory, biochemi-cal, histological, cytoflourometrical, instrumental, sonographic, laparoscopic, statistics; results - find out the objective features of the flow of victims to the trauma of the liver, depending on the structure of the liver injury, mechanism of injury and examined histological features of morphological changes of the liver cells, depending on the type of injury and its distribution, the first time a study of hepatocyte apoptosis in different types of injuries and proved the need for a hepatoprotector patients with blunt trauma to the liver, first developed the original device to model the closed blunt trauma to the liver in an experiment, improved diagnostic-therapeutic algorithm in traumatic injuries of the liver, developed a method of linking the damaged liver tissue and how to prevent liver failure; branch – medicine.