Mykhaylyshyn L. Causes and prevention of repeated in vitro fertilization failure.

Object - repeated negative attempts fertilization in vitro (IVF) purpose - to increase the effectiveness of programs assisted reproductive technologies by developing and implementing in practice diagnostic and therapeutic algorithms of patients with repeated IVF attempts negative based on a comprehensive study of their genesis, methods - clinical, biochemical, cytofluorymetrical, immunohemiluminescent, ELISA, sonographic, morphologic, statistics, results - expanded existing data on the factors and the incidence of embryonic implantation and repeated negative factors IVF attempts, established the importance imbalance of cytokines and lymphocyte subpopulations in the genesis of failures IVF attempts, defined markers repeated negative IVF attempts; shown that increased TNF-?, IL-2 and lower levels of IL-6, IL-4 and IL-10 in peripheral blood is a prognostic marker of recurrent IVF failures and PE obtained new data on the predictive value of success IVF programs comprehensive study of mark-ers autoimmune processes, levels and activity of NK-and NKT cells in the peripheral blood, indications to the use of immunotherapy in the management of women with repeated IVF attempts negative and proved the effectiveness of the proposed immune corrective therapy developed and proven effective diagnostic and treatment algorithm of patients with repeated negative attempts IVF; branch – medicine.