Grudko I. 3.The pharmacognostic research of Melilotus L. genus specias from Ukrainian flora

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0413U002497

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

05-04-2013

Specialized Academic Board

Д 64.605.01

National University of Pharmacy

Essay

The thesis is devoted to the complex pharmacognostic study of biologically active substances from Melilotus L. genus species from Ukrainian flora. At the first time the morphological and taxonomic studies of 10 species and pharmacognostic and chemotaxonomic studies of seven species of the genus Melilotus L. flora of Ukraine were carried out. As the result the content of hydroxycinnamic acids, coumarins, tannins, flavonoids, 110 constituents of essential oils, organic acids, amino acids, carotenoids, chlorophylls, macro- and micronutrients they are determined; 19 phenolic compounds and cyclohexanіc alcohol – inositol have been obtained; promising species as sources of biologically active substances have been choosen that could be used as base for receiving pharmacological drug substance with antimicrobial, antitumor and anticoagulating action were identified. The methods of quality control for the raw material were worked out. Description, identification and testing of the method of thin layer chromatography, quantification of coumarins and flavonoids were complied.

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