Usinskyi R. Sex features of cholinergic regulation of the rat heart in epinephrine damage conditions with a blockage of ATP-sensitive potassium and calcium channels as a background.

Object - the cholinergic regulation of the rat heart in epinephrine damage; the purpose - to study the characteristics of cholinergic regulation of heart in the development of necrotic process on the background of blockage of ATP-sensitive potassium and calcium channels, depending on gender and activity of the gonads; methods - electrophysiological,biological biochemical, morphological, mathematicaland the results -It was found that blockage of ATP-sensitive potassium channels in females leads to increased cholinergic activity in autonomic regulation of heart rate with reducing of adrenergic activity, accompanied by increased sensitivity of the heart only to endogenous acetylcholine; blockade of calcium channels leads to decrease of adrenergic activity level of autonomous regulation in animals of both sexes and increases the cholinergic activity only in males; the development of the necrotic process in the myocardium of rats with blocked both ATP-dependent potassium and calcium channels is associated by the decrease of adrenergic control of the heart with increased cholinergic control in animals of both sexes; blockage of ATP-dependent potassium channels in animals after gonadectomy leads to weakening of the adrenergic and increasing of cholinergic influences of the autonomic nervous system on heart activity in animals of both sexes, and the blockage of calcium channels - only in males; honadektomy doesn't change the type of reactions in the hearts of females and males after administration of exogenous acetylcholine and stimulation of the vagus nerve in the blockage of ATP-dependent potassium and calcium channels; development of adrenaline myocardial injury in rats after gonadectomy with blocked calcium channels does not change the direction of regulatory influences of the autonomic nervous system on heart rate in animals of both sexes, but in blockage of ATP-dependent potassium channels adrenergic effects are limited only in males; development of adrenaline myocardial injury in a blockage of ATP-dependent potassium channels is accompanied by an increasing number of necrotic cardiomyocytes, but in condition of calcium channel blockade it is reduced in animals of both sexes, regardless on the gonads activity.