Krychynska I. Inhibitor of phosphodiesterase-5 therapy impact on erythrocytes NO-system condition and endothelin-1 level in patients with pulmonary arterial hypertension.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0413U003487

Thesis Registration Form

0413U003487.pdf

Applicant for

Specialization

  • 14.01.11 - Кардіологія

23-05-2013

Specialized Academic Board

Д 26.616.01

State Institution National Scientific Center "The M.D. Strazhesko Institute of Cardiology National Academy of Medical Sciences of Ukraine"

Essay

The basis of the data are of clinical and instrumental examination of 61 patients with pulmonary arterial hypertension. Found that long-term therapy with phosphodiesterase-5 inhibitor sildenafil leads to increased exercise tolerance, reduced systolic pressure in the pulmonary artery, reducing the size of the right ventricle. Long-term therapy with sildenafil has a positive effect on the dynamics of ET-1 and VWF activity in plasma. Described state of NO-system of erythrocytes in patients with PAH and its changes under the influence of sildenafil therapy. We describe the factors that increase the likelihood of poor response to sildenafil therapy.

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Files

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Диссертация 6 april 2013.docx

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