Bondarchuk О. Synthesis and biological activity of new glycoside derivatives of quinones

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0413U003576

Thesis Registration Form

0413U003576.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

24-05-2013

Specialized Academic Board

Д. 35.600.02

Essay

This thesis are devoted to the development of effective methods of organic and bioorganic synthesis of new glycosylated naphtho- and anthraquinones, establishing the structure, physical and chemical characteristics; research in biological activity of newly synthesized compounds. Based on the reactions of nucleophilic substitution of chlorine atom of 2,3-dichloro-5-R-1,4-naphthoquinone amino acid derivatives by glucosamine fragment and their interaction with glucosamine the number of glucosyl derivatives of naphthoquinones were received. Using bacteria Sacharothrix espanaensis a number of ramnozylcontaining anthraquinones were obtained through bioorganic synthesis.; industry - pharmacy.

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