Zhukovska A. The influence of fatty acid composition modification of cell membranes on mechanisms of heart dysfunction in experimental diabetes

Thesis deals with the systematic and molecular mechanisms of heart disorders in experimental diabetes type І and their correction by modifying the fatty acid composition of cell membranes. Modification was performed by omega-3 PUFAs (Epadol, comprising at least 43% esters of eicosapentaenoic and docosahexaenoic acids) and according to the results of experimental studies we found that this acids have cardioprotective properties. It is noted that fatty acid composition modification of myocardial cell membranes restores affected bioenergetic functions of mitochondria, isolated from heart tissues, in animal research groups. Analysis of the data indicates that usage of omega-3 PUFA leads to cardiohemodynamics recovery, restores disturbed pro/antioxidant balance, normalizes structure, expression and immunofluorescent signal of connexin 43 protein in experimental conditions. Thus, the results of our work show promising application of cell membranes fatty acid composition modification by omega-3 PUFAs for the prevention of cardiovascular disease in diabetes.