Husarov V. Synthesis, properties and application of functionalized cholic acid derivatives.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0413U004574

Thesis Registration Form

0413U004574.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

26-06-2013

Specialized Academic Board

Д 64.605.01

National University of Pharmacy

Essay

The aim of this work was synthesis of cholic acid with functionalized carboxyl group (esters, alkyl-, aryl-, heterylamides), 17-(4-(1,2,4-oxadiazol-5-yl)butan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a] phenanthrene-3,7,12-trioles and their isomers, and R-3-(5-(1-methyl-1-(3,7,12-trihydroxy-10,13-dimethylgonan-17-yl)-prop-3-yl)-1,3,4-oxadiazol-2-yl)-coumarins. Synthesized glycocholic acid was used for water-soluble form of vitamin K1 obtaining. The using of fluorescent cholic acid derivative 7-(diethylamino)-3-(5-(1-methyl-1-(3,7,12-trihydroxy-10,13-dimethylgonan-17-yl)-prop-3-yl)-1,3,4-oxadiazol-2-yl)-2H-chromen-2-one as a marker of fatty acids absorption was proposed and investigated. Quality control methods for this compound have been drafted.

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Files

aref.docx

Дисертация_Гусаров_final.pdf

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