Anatskaya Y. Reactions of peroxomonosulphuric acid with tertiary amines and its application in pharmaceutical analysis.

Thesis is dedicated to investigation of new procedures of quantitative determination of medicinal preparations that contain tertiary amine using new analytical reagent – potassium hydrogenperoxomonosulphate. N-oxidation reactions kinetics obey general laws of specific alkali-acidic catalysis, is quantitative and stoichiometric by the mechanism of nucleophilic substitution of peroxomonosulphate ions peroxidic group oxygen ?-atom was determined. N-oxidation reaction using potassium peroxomonosulphate was proposed as analytical reaction on alkaloids in quantitative pharmaceutical analysis for the first time. The possibility of quantitative determination of tertiary amines using КНSO5 by iodometric titration and spectrophotometric by the residue of unreacted КНSO5, and also by the method of indirect voltammetry in the form of appropriate aminoxides were theoretically shown and experimetally proved.