Kachan I. Quality of life and ways of its improvement in patients with stage II of essential hypertension in combination with abdominal obesity, dyslipidemia and insulin resistance

The thesis is presented for the Scientific Degree of Candidate of Medical Sciences in speciality. The thesis (dissertation) is devoted to improving the treatment of patients with hypertension in combination with abdominal obesity, dyslipidemia and insulin resistance based on detection factors reducing the quality of life of patients and the development trends of correction. Significant prevalence of abdominal obesity, dyslipidemia and insulin resistance was found in patients with hypertension and confirmed negative impact of mentioned factors on morphofunctional heart state and blood vessels. It was shown the impact of obesity on the patient's life quality. It was shown that one of the most sensitive to the morphological changes of heart and blood vessels is a component of physical functioning. Demonstrated relationship between the decline in quality of life and headache, dizziness, false angina, the frequency of hypertensive crises, the presence of anxiety on measured by HADS scale. Was found low adherence to medication and lifestyle modifications in patients. The leading role of informing patients about the presence of risk factors, the threat of complications and the need for continuous treatment improved adherence was proven. The leading factor in improving the quality of life is acceptable adherence to medicines treatment and lifestyle modifications. It was found that fixed combination of ACE inhibitor / diuretic or ACE inhibitor / calcium channel blocker with receiving 1 tablet a day is the best variant of therapy for improving the parameters of quality of life and maintaining the patient's adherence to medicines.