Mazur I. Clinical and prognostic value of endothelial nitric oxide synthase and I/D angiotensin-converting enzyme gene polymorphisms in chronic heart failure.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0413U005022

Thesis Registration Form

0413U005022.pdf

Applicant for

Specialization

  • 14.01.11 - Кардіологія

19-06-2013

Specialized Academic Board

Д 26.616.01

State Institution National Scientific Center "The M.D. Strazhesko Institute of Cardiology National Academy of Medical Sciences of Ukraine"

Essay

The basis of the data is of clinical and instrumental examination of 116 ischemic chronic heart failure (CHF) patients (pts) with left ventricular (LV) systolic dysfunction. Flow-mediated vasodilation (FMD) in pts with genotype CC of eNOS T (-786) C polymorphism was reduced more in comparison to FMD pts with TT and TC genotypes. FMD in pts with genotype GG of eNOS G894T polymorphism was reduced more in comparison to FMD TT pts. FMD does not depend on class NYHA and EF LV. The pts with genotype CC of eNOS T (-786) C polymorphism have demonstrated significantly worse 30 month prognosis as compared to TT pts.

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Files

АВТОРЕФЕРАТ--Диаграма.doc

АВТОРЕФЕРАТ--Мазур-автореферат.doc

АВТОРЕФЕРАТ--Титульна сторінка автореф.doc

АВТОРЕФЕРАТ--Титульна сторінка автореф2.doc

Об'єднана дисертація 8.07.doc

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