Shepotinnyk E. Clinical-paraclinical criteria for assessing the efficacy of thrombolytic therapy and its possible potentiation

Found that in patients with ischemic stroke after thrombolytic therapy is rapid leveling of the neurological deficit, the stabilization of coagulation hemostasis and reduce the severity of oxidative stress in comparison to the control group - patients with ischemic stroke whom thrombolytic therapy was not performed. Based on the study identified a range of measures to reduce the pre-hospital and hospital time loss, providing more early thrombolytic therapy, thereby improving outcomes. A number of regularities in the dynamics of blood pressure, regression of neurological impairment, depending on the data computed tomography of the brain and lipid peroxidation. The comparison with the international scale NIHSS, Rankin, Barthel reflected the trend of regression of focal neurological symptoms and the degree of daily activities of patients. The appropriateness of measures to reduce the pre-hospital, hospital wasting an citicoline neuroprotection in order to potentiate the effect of thrombolytic therapy.