Sudorenko G. Influence of low doses of ionizing irradiation on heart rate variability in Chernobyl accident clean-up workers with essential arterial hypertension

The dissertation is dedicated to the heart rate variability (HRV) of Chernobyl accident (ChA) clean-up workers (CW) with essential hypertension (EH), the importance of radiation and non-radiation factors and their interaction in the development of HRV violations, identify opportunities preservation and restoration of the HRV and associated disruption to its changes. It is shown that an increase in sympathetic and decrease parasympathetic activity in ChA CW even without cardiovascular diseases. Violations of HRV in ChA CW are registered in an earlier age interaction lasting increase in sympathetic activity and irradiation and non-irradiation factors. A correlation between HRV indexes and catecholamine excretion and based on defined markers hypersympathetic activity. The correlation between the disorders of HRV parameters and external radiation dose > 250 mSv, duration of work on ChA CW > 30 days is discovered, hypersympathetic activity is associated with a greater degree of left ventricular hypertrophy, decreased physical exercise. Preconditions recovery HRV violations, based on EH treatment strategy are determined. The advantages of the combined use of antihypertensive drugs first line that provides improved HRV, achieving target blood pressure, reducing the mass and thickness of the myocardium, improving exercise tolerance and preserving them for long-term treatment.