Baiyda M. Pathogenetic mechanisms of prooxidant and antioxidant systems disturbances under condition of experimental allergic alveolitis development and their correction with thiotriazoline.

OObject - the process recreated on porpoises with use of experimental model allergic alveolitis; the purpose - to define a role and features of changes of prooxidant and antioxidant systems in bodies of breath in pathogenetic developments experimental allergic alveolitis and to establish their correction with thiotriazoline; methods - biochemical, mathematical; results - The dissertation work is devoted to the investigation of role and peculiarities of functional condition of prooxidant and antioxidant systems in pathogenesis of experimental allergic alveolitis and their correction with thiotriazoline. Gradual intensive accumulation of lipid peroxidation products, begining from early period (from 24-th day) has been revealed for the first time, which was the most obviously manifested firs of all in the lungs and bronchi, less in the trachea and blood and reached the highest indexes on the 54-th day of allergic alveolitis development. The compensatory increase in ceruloplazmine activity and peroxidase, superoxide dismutase, catalase on the 24-th day of experiment has been shown for the first time. These indicators increased considerably first of all in the lungs and bronchi and other ones - activity of peroxidase and ceruloplasmine in the trachea and activity of superoxide dismutase and catalase in the blood were on the same level with intact animal group. Evident corrective influence of thiotriazoline on disturbed functional condition of prooxidant-antioxidant system, which was manifested by decreased level of diene conjugates, malonic dialdehyde and increased activity of superoxide dismutase, catalase, peroxidase and ceruloplasmine in the lungs, bronchi, trachea and blood in development of allergic alveolitis has been proved for the first time.