Korovka S. Mechanisms of endogenous intoxication syndrome at traumatic disease in brain injury

A research object is the experimental dosed cranial-cerebral trauma, mechanisms and stage of endogenous intoxication syndrome development at traumatic cerebrum illness; purpose - mechanisms, stage and pathogenetic endogenous intoxication syndrome role at cerebrum traumatic illness, diagnostic criteria ground and directions of exposed violations correction; methods - immunoenzyme; biochemical and statistical; novelty and results - the stages of endogenous intoxication syndrome forming at cerebrum traumatic illness characterized: hiperergyc reaction of the neuro-endocrine systems, hypermetabolism, hyperglycemia and insulinoresistence; expressed enzyme, endogenous intoxication and generous inflammatory reactions; system hypoxia, middle mass molecules increase, antioxidant system exhaustion and inflammatory processes activating; metabolism deep violation forming, middle mass molecules piling up, nervous and myocardium damage, cerebrum hypermetabolism traumatic illness, violation of metabolism increasing and hyperglycemia; progress neurodistruction, progress middle mass molecules accumulation in the organism was a next mechanism; it is inculcated - in practice Neuro-surgical aid № 1 Donetsk regional clinical territorial medical association, surgical and neuro-surgical clinics of Institute of urgent and restoration surgery and science of trauma and orthopaedy of the Donetsk national medical university, in a pedagogical process on the departments of pathological physiology of the Donetsk national medical university, Zaporozhian state medical university, Lugansk national medical university, Crimean state medical university; the use of industry is the scientific and pedagogical processes of departments of pathological physiology, neuro-surgery, anaesthesiology and histology of medical educational establishments, medically-diagnostic process of separations of neuro-surgery, laboratories and diagnostic centers.