Bodnarjuk O. Diagnostics and Treatment of the Salpingo-Oophoritis on the Background of the Inflammatory Diseases of the Kidneys and Urine Bladder in the Adolescent Girls.

The thesis is dedicated to investigation of the problem of the inflammatory diseases of internal genitalia combined with inflammatory urological pathology in the adolescent girls. It has been established that urological pathology has the negative influence on microflora and its load in vaginal content what intensifies the process of inflammation. It has been showed that the peculiarities of the immune status are seen as the changes of the immune and hematologic parameters and coefficients which results in forming of the tendency to growth of the concentration of pro-inflammatory and anti-inflammatory cytokines in the peripheral blood. The extent of the growth is in proportion to microbial load and to presence of urologic pathology. The clinical and diagnostic criteria for diagnostics and treatment was proposed which are built on the basis of the clinical, microbiologic and immunologic indexes. The pathogenetically substantiated complex of treatment of the salpingo-oophoritis combined with the inflammatory diseases of kidneys and urine bladder has been proposed basing on the obtained information. The developed pathogenetically substantiated complex of treatment is reliably more effective and causes the normalization of the concentrations of the pro- and anti-inflammatory cytokines as well as sIgA which are approaching to the indexes seen in practically healthy adolescent girls.