Babanin V. Immuno-morphological criteria of treatment efficacy in patients with psoriasis during narrow-band ultraviolet B (311 nm) therapy

The object of study - psoriasis. The purpose of the study - improving the efficacy of treatment of plaque-type psoriasis during narrow-band ultraviolet B (311 nm) therapy on the basis of a study of immune response. Methods: clinicо-laboratory, immuno-morphological, instrumental, statistics. Chronic inflammation in psoriasis is associated with increased serum cytokines (TNF-?, IL-6, IL-22) and upregulation of macrophages and T lymphocytes in psoriatic site and accompanied by dissociation with clinical parameters of disease severity. Polymorphism of clinical response to UV irradiation is associated with varying degrees of immunosuppression, which allows to identify criteria for the appointment of erythmogenic (more aggressive) or suberythmogenic (less aggressive) strategies for NB-UVB (311 nm) therapy. Results have been implemented in the practice of educational, scientific and medical complex "University Hospital" of SE "Crimean State Medical University named after S.I. Georgievsky", ME "Zaporizhzhya Regional Clinical Skin and Venereal Diseases Dispensary", as well as in the educational process of the department of skin and venereal diseases of SE "Crimean State Medical University named after S.I. Georgievsky", the department of family medicine with courses dermatovenerology and psychiatry of SE "Zaporizhzhya Medical Academy of Postgraduate Education", department of dermatovenerology and cosmetology FPE Donetsk National Medical University named after M. Gorky, the department of dermatology and venereology of SE "Lugansk State Medical University". Use area - dermatovenerology.