Gavaleshko V. Biochemical and morphological correlatеs of parenchymal organs reaction to the brain ischemic-reperfusion damage in male rats with streptozotocin-induced diabetes mellitus.

Object -streptozotocyn-induced diabetes with the ischemic and reperfusion damage of the brain; the purpose - to establish pathobiochemical characteristics of the pathogenesis of a damage of the myocardium and kidneys in rats with complication of the streptozotocin-induced diabetes mellitus by incomplete global ischemia-reperfusion of the brain; methods - physiopathologycal, biochemical, mathematicaland the results -It has been established that diabetes mellitus modifies the pathobiochemical reaction of myocardium of the left ventricle, cortex and medullary substance of the kidneys on ischemia-reperfusion of the brain. It has been shown that in the myocardium and marked departments of the kidneys of the animals without diabetes on the 12-th day of post-ischemic period the most investigated biochemical indices remains disturbed, whereas under conditions of 4-month experimental diabetes the reaction according to many parameters in both terms of supervision is substantially limited or absent, regardless of more considerable destructive changes in the tissues of these organs in comparison with the animals without diabetes; it has been shown both general and organospecific conformities of reacting of the myocardium and kidneys to the brain ischemia-reperfusion, however specific manifestations of the reaction in rats with the presence of diabetes to a considerable degree аrе lost; it has been stated that pathomorphologycal changes in the myocardium under conditions of separately modelled diabetes and ischemia-reperfusion of the brain differ quantitatively, and in the kidney corpuscles specific displays take place for every discased condition. Additive effects of destructive changes are observed in combination of the defined experimental models.