Skoroplit O. Optimization of general anesthesia influence a cognitive impact in young patients with maxillofacial pathology

In the study the influence of methods of general anesthesia with mechanical ventilation on the state of cognitive function evaluated in 105 young patients with maxillofacial pathology in the postoperative period. Patients are divided into 3 groups: group 1 (n=34) underwent general anesthesia with sodium thiopental and fentanyl, group 2 (n = 31) general anesthesia with propofol and fentanyl, group 3 (n = 40) underwent inhalation anesthesia with sevoflurane and fentanyl. The markers of stress (cortisol level, HOMA index and sympatovagal balance) were determined on 4 stages (before surgery, on the main stage of the operation, a day after surgery, in 7 days after surgery). Cognitive functions (concentration and persistence of the attention (Burdon test), memory status (Luria test) and biological intellectual coefficient (Raven test) were studied in 3 stages (before surgery, a day after surgery and in 7 days after surgery). It was found that the higher intensity of stress reactions during anesthesia leads to more severe cognitive dysfunction after surgery, especially a day after it. Also it was found that sevoflurane provides the best anti-stress protection in comparison with sodium thiopental and propofol. Sevoflurane had less influence on cognitive function in the postoperative period. Propofol caused moderate depression of patients' cognitive state. Sodium thiopental leads to the greatest inhibition of cognitive functions.