Hafiichuk N. Optimization of diagnostics and treatment of hypothalamo-pituitary dysfunction in women with anovulatory infertility.

The paper deals with increasing the efficiency of treating anovulatory infertility associated with hypothalamo-pituitary dysfunction by optimizing the techniques for forecasting, diagnostics and treatment of the disorder and improving the algorithm of the suggested treatment and preventive steps. The frequency of hypothalamo-pituitary dysfunction in the structure of anovulatory infertility has been determined. The connection between the psychological and emotional factors and the functional disorders of the hypothalamo-pituitary ovarian system has been established. The hormonal, functional and genetic biomarkers have been defined, allowing to predict a complete pattern of a woman's reproductive status. The work adds to the data on pathogenesis of anovulatory infertility and allows a scientific improvement in the algorithm for preparation of women with anovulatory infertility associated with hypothalamo-pituitary dysfunction to the use of Assisted Reproductive Technologies. A new approach to the management of women with anovulatory infertility associated with hypothalamo-pituitary dysfunction has been suggested, using an adapted etiopathogenetic stimulation protocol in the Assisted Reproductive Technology programs. The work provides a developed and scientifically justified set of diagnostic and treatment steps for women with anovulatory infertility associated with hypothalamo-pituitary dysfunction, which allows a 1.7 increase in the treatment efficiency using the above method and a threefold cut in the cost of treatment.