Yarema V. Pathogenetic peculiarities of the polytrauma course of the individuals with a different metabolic ability of the liver.

Object - pathogenetic features of development of dysfunction of a liver in conditions of a polytrauma; the purpose - reveal of feature of course of the early period of a polytrauma at rats з different metabolic ability function of a liver in experiment, methods - functional; biochemical; morphological; mathematical; the results - The dissertation is devoted to the peculiarities of the early period of polytrauma of rats with a different metabolic function of the liver. The method of distribution of laboratory white rats with fast, medium and slow type of liver metabolism is elaborated, its based on determine of duration of tiobarbituric sleep. It is proved that in the conditions of polytrauma slowly and high metabolic rats are characterized by oscillatory character of microsomal liver function, which slows down in 2 hours after polytrauma and increased after 1 day, with further normalization in high metabolic animals and the second wave of slowing down of slow metabolic animals. It is found that in response to polytrauma is observed increasing of activity in the blood serum of aspartate and alanine aminotransferase, and alkaline phosphatase, that at maximum of increasing are higher in slowly metabolic animals. It is also found that in response to polytrauma in slow metabolic animals depth of lipids peroxidic oxidation, abnormalities of antioxidant protection and endotoxemia are larger than in the fast metabolic animals. Peculiarities of bile creating liver function in animals with different types of metabolism in dynamics of the early period of polytrauma are shown, maximum of deviations occurs in 3 days, and they are significantly higher in slow metabolic rats. It is shown that in response to injury of rats with different metabolic ability is observed increasing of liver mass coefficient that is significantly higher in slow metabolic rats. It is clarified that the total death of slowly metabolic rats under the influence of polytrauma in 1.92 times higher than in the fast metabolic rats.