Bobrova O. Chronic Acquired Toxoplasmosis: Criteria of Diagnosing and Treatment

The thesis is dedicated to the improvement of the diagnostics and treatment of the patients sick in chronic acquired toxoplasmosis in the acute stage. The statistical analysis of toxoplasmosis sickness rate in Kharkov region and in Ukraine for the period of 2005-2011 is conducted. The diagnostics criteria of the acute stage of CAT are specified based on the studies of the clinical symptoms instrumental examination (electric encephalogram, ultrasound examination, and electric cardiogram), laboratory data (clinical blood test, thymol test, general and direct billirubin, alanine aminotransferase, aspartat aminotransferase) and immunological examination. The nature of infraction of the immunological homeostasis is determined, the range evaluation of the degrees of aberrance of different elements of immunity is conducted, and the level of restructuring of the body functional system influenced by toxoplasmosis is specified with the help of the system analyses (method of correlative structures). The block scheme of the immunological factors of pathogenesis of CAT is worked out. The efficiency of the complex treatment of the acute stage of CAT with anti-protozoan therapy (APT) with a combined preparation pyrimethamine+sulphadoxine, the specific immunoglobulin against T. gondii of human and their combinations based on the research of the nature of dynamics of clinical, laboratory, instrumental and immunological data in 1month and 6 months from the beginning of the treatment are defined. The torpid of the maximum therapeutic effect of the 6th month from the beginning of the treatment is found out.